Tumor induction in B6C3F1 mice by californium-252.

Progress in Californium-252 Neutron Brachytherapy

The potential of using Cf-252 to treat cancer patients was first described by Shlea and Stoddard in 1965 as a source of neutrons using brachytherapy procedures [Stoddard, 1986]. In the late 1960’s and early 1970’s, the United States and England initiated human clinical trials of Cf-252 neutron brachytherapy (NBT) for treating patients of various cancer types. These earlier trials treated only v...

Californium-252 neutron sources for medical applications.

Teratogenic effect of californium-252 irradiation in rats.

The teratogenicity of californium-252 (Cf-252) irradiation which generates approximately 70% 2.3 MeV fast neutron and 30% gamma rays was evaluated. A single whole body exposure of Cf-252 at various doses was given to pregnant rats on day 8 or 9 of pregnancy, followed by microscopic autopsy of the fetuses at the terminal stage of pregnancy to search for external and internal malformations. For c...

Californium-252 plasma desorption with Fourier transform mass spectrometry.

Sir: Plasma desorption (PD), such as that induced by the 100-MeV fission products of z5zCf, is a particularly promising ionization method for large molecules (1-5), yielding molecular inn species even from trypsin, molecular weight 23463. Further, with trypsin using nitrocellulose as the substrate, (M + 3H)3+ is the most abundant molecular ion species and (M + 6H)fi+ is measurable ( 4 ) , which...

Induction of apoptosis in human tumor cell lines by platelets

Introduction: It has been reported that platelets can eradicate tumor cells in vitro, although the mechanism of this effect has not been determined. The effect of platelets on the induction of apoptosis in tumor cells is largely unknown. Materials and methods: To investigate this effect, two human hematologic cell lines, K562 and Daudi, were independently faced with unstimulated and thromb...